Chemical Database of Traditional Chinese Medicine
Chem-TCM database started with Dr. Tom Ehrman research work prior to him joining his supervisors, Professor Peter Hylands and Dr. David Barlow, in the Institute of Pharmaceutical Science at King’s College London. The database completion became possible with the successful application for the funding from Innovation China-UK (ICUK) initiative in collaboration with Professor Weiliang Zhu and his group from the Shanghai Institute of Materia Medica, China. The assembly of the dedicated research team was complete with Dr. Javed Nazir at KCL and Professor Zhu with his PhD student, Xuelian Zhu, in Shanghai.
Dr. David J. Barlow is a Reader in Computational and Molecular Biophysics in the Institute of Pharmaceutical Science at King’s College London. He graduated in Biochemistry at University College London; and subsequently, at Birkbeck College, completed an MSc in Biomolecular Structural Organisation, and then later a PhD in Crystallography. Since 1985, he has worked in the Institute of Pharmaceutical Science at King’s College London. His research over recent years has been primarily concerned with structural and computational studies of drugs and drug delivery systems. These studies have included: informatics and virtual screening of phytochemical libraries; development of expert systems approaches for drug discovery and modelling of drug delivery; development of novel software for modelling membrane structure; detailed characterisation of the molecular architectures of gene delivery vehicles; and the development of novel systems for heterologous expression of eukaryotic integral membrane proteins. He has over 90 research papers, reviews and book publications to date.
Professor Peter J. Hylands started his career with academic appointments in the University of Strasbourg, as a Royal Society European Fellow, and then in the University of London. His special research interest has always been natural products in medicine. He joined the commercial world in 1988 as Director of Chemistry and then Research Director of biopharmaceutical companies in the UK and the USA. He has consulted for the United Nations and Commonwealth Science Council. He has worked or collaborated with institutions on every continent regarding natural medicines and natural product research and development. He serves on a number of boards, advisory boards and government committees and is currently Joint Head of the Institute of Pharmaceutical Science, King’s College London. His current research emphasises the application of chemometrics and emerging biotechnologies to the problems of standardisation and quality control of plant medicines. He has a research group in the Centre for Natural Medicines Research, King’s College London of which he is Director.
Dr. Tomas M. Ehrman graduated in Natural Sciences at Cambridge University, and subsequently studied for Masters degrees in Plant Genetics and Computational Chemistry at Cambridge, and Darwin University, Australia, respectively. His PhD in Pharmaceutical Science (entitled Phytochemical informatics of plants used in traditional Chinese medicine) was completed under the supervision of Dr David Barlow and Professor Peter Hylands in the Institute of Pharmaceutical Science at King’s College London. Tom also has a Diploma in Chinese Herbal Medicine gained through the London School of Chinese Herbal Medicine, and is a member of the Register of Chinese Herbal Medicine, UK.
Dr. Javed Nazir graduated in Electrical & Electronic Engineering at the University of Hertfordshire. His Astra-Zeneca funded PhD in Pharmaceutical Science (entitled The use of artificial neural networks to predict medical aerosol behaviour within the human respiratory tract) was completed under the supervision of Dr David Barlow and Professor Jayne Lawrence in the Institute of Pharmaceutical Science at King’s College London.
Funding for the database project development was secured through Innovation-China UK.
The research team is indebted to the many people who made great contribution to gathering the information on chemical constituents of Chinese (and other) herbs – in particular, the late H.Y. Hsu, Y.P. Zhu, H.M. Chang, P.P.H. But, X. Yan, J. Zhou, G. Xie, K.C. Huang, J. Duke and G. Polya.